SpaReg: sparsity-based 3D reconstruction of tissue microenvironments at native resolution across morphological and spatial molecular modalities
Tissue microenvironments comprise cellular and acellular components whose three-dimensional (3D) architecture guides disease fate. Direct imaging of intact specimens by light-sheet and multiphoton microscopy, and computational reconstruction from serial sections, have established that 3D spatial context reveals cell and tissue organization inaccessible at single planes. Computational…
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