Alcohol Use Disorder and Smoking-Associated Molecular Alterations in Human Prefrontal Cortex in Single Nucleus (sn) RNA-Seq
Chronic smoking worsens alcohol related brain injury and impairs neurocognitive recovery, yet the cell type specific molecular interactions between alcohol use disorder (AUD) and smoking in the human brain remain largely unexplored. We analyzed single-nucleus RNA-seq from the prefrontal cortex of 73 individuals (614,932 nuclei, 24 cell types), comparing AUD versus controls, smoking versus…
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