A model for within- and between-host evolution in pathogens
Many pathogenic and microbial species undergo complex life cycles wherein they experience drastic bottlenecks during invasion into a host and rapid growth within hosts. The effects of such a complex population history on patterns of genetic variation is not currently understood. We model a pathogen population as a metapopulation where each deme represents a host and incorporate transmission…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
