'Use lowest effective dose of Nsaids': Fresh advisory on kidney risks of painkiller abuse

The Central Drugs Standard Control Organisation (CDSCO) has issued a new advisory urging responsible use of painkillers and antibiotics. These prescription medicines can cause kidney complications and other side effects when overused without proper medical guidance. The drug regulator warns that non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics should only be taken when clinically necessary, at the correct dose and duration, and under a physician's supervision.

CDSCO advises people to avoid prolonged use of NSAIDs, commonly used as painkillers, without proper medical advice. Those with existing kidney disease or other risk factors for renal impairment should inform their doctors before taking NSAIDs. Renowned nephrologist Prof Sandeep Mahajan of AIIMS explains that unregulated and prolonged use of painkillers can hasten kidney function decline.

The CDSCO recommends doctors prescribe the lowest effective dose of NSAIDs for the shortest appropriate duration, with extra caution for patients at risk of kidney injury. This advisory comes amid India's high chronic kidney disease burden, with a 2025 review estimating a 13.24% pooled prevalence, though estimates vary by region and study.