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Unveiling the small protein landscape of uropathogenic E. coli

Uropathogenic Escherichia coli (UPEC) is the predominant causative agent of urinary tract infections. The UPEC strain, CFT073, has a mosaic genome containing 60 genomic islands enriched in virulence genes. In this study, we explore the small proteome of CFT073 using ribosome profiling (Ribo-seq) coupled with RNA sequencing (RNA-seq), and reveal 338 translated, previously unannotated, putative…

biorxiv.org ·1d ago

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