Protection from TB preventive treatment could wane after one year in high-burden countries: Study
The results showed that high-burden countries should consider combining TPT with other interventions to achieve the long-term benefits these medications are capable of providing
A new study published in The Lancet Respiratory Medicine suggests that protection from tuberculosis preventive treatment (TPT) may wane after just one year in high-burden countries, according to researchers from Boston University and the University of California, Berkeley. While TPT offers strong initial protection during the first 12-24 months across all settings, its long-term effectiveness varies depending on the burden of TB disease in each region.
The research, which included 84,128 participants from 44 cohort studies across 24 countries, found that TPT is highly effective in preventing TB progression among close contacts and people infected with the disease. However, the initial effect of TPT declined rapidly in high-burden settings, leading researchers to recommend combining TPT with other interventions to achieve long-term benefits and address ongoing community transmission.
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