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Interferon gamma-induced MX1 and IFITM1 inhibit Varicella-Zoster Virus Replication

Interferon gamma (IFN-{gamma}) is a potent cytokine secreted following primary varicella-zoster virus (VZV) infection. Our previous studies demonstrated that pretreatment with IFN-{gamma} completely inhibited VZV replication in lung fibroblast MRC-5 and retinal epithelial ARPE-19 but not in melanoma MeWo cells, suggesting that IFN-{gamma}-stimulated protein(s) inhibit viral replication. Our…

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David N. Spergel

Director: Center for Computational Astrophysics, FlatironCharles Young Professor Emeritus, Princeton UniversityCo-Chair: NASA WFIRST Form.

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