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Cooperativity through Allee Effects drives growth of diffuse midline gliomas impacting the optimal scheduling of therapeutic interventions

Diffuse midline gliomas are a group of tumours for which no effective therapies exist. These tumours have substantial intratumoural heterogeneity and harbour beneficial subclonal interactions. Therapeutic failure due to resistance is a major concern in these tumours. We demonstrate how distinct subpopulations derived from the same tumour can interact with one another to alleviate the impacts of…

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David N. Spergel

Director: Center for Computational Astrophysics, FlatironCharles Young Professor Emeritus, Princeton UniversityCo-Chair: NASA WFIRST Form.

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