Cargo size matters when designing lipid nanoparticles for delivery of large gene editors
Nature Biotechnology, Published online: 28 September 2026; doi:10.1038/s41587-026-03297-9 Lipid nanoparticles often show reduced performance when delivering the large messenger RNAs that encode gene editors. Screening ionizable lipids with a gene-editor-sized RNA identified LC-1, which forms a structure that enhances endosomal escape and enables efficient genome editing in the liver, lung and…
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