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Additional blood meals increase mosquito infectivity by accelerating the transcriptional development of Plasmodium sporozoites

Sporozoites, the infectious stage of Plasmodium malaria parasites, must invade two different tissues in two very different hosts to ensure transmission: the mosquito salivary glands and the human liver. Whether infectivity to hepatocytes is affected by physiological components, such as the availability of nutrients within the Anopheles female, is not well understood. Here we show that Plasmodium…

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David N. Spergel

Director: Center for Computational Astrophysics, FlatironCharles Young Professor Emeritus, Princeton UniversityCo-Chair: NASA WFIRST Form.

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