Exercise and Cancer Survival; COVID Vaccine and Immune Checkpoint Inhibitors
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A recent meta-analysis of randomized controlled trials suggests that structured exercise after cancer treatment can improve overall survival, disease-free survival, and cancer-specific mortality. The study included nearly 8,500 participants, primarily women with breast cancer, and found a 23% benefit in overall survival, with similar improvements in disease-free survival and all-cause mortality.
The authors speculate that exercise may enhance the infiltration of cytotoxic T cells and natural killer cells into tumors, increase drug penetration, and reduce tumor glucose levels. However, the data did not consistently address progression-free survival or pathological complete response.
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