Potency of nucleoside analogs against Powassan virus replication and identification of 4'-fluorouridine as a therapeutic candidate for tick-borne orthoflavivirus encephalitis
Powassan virus (POWV) is an emerging tick-borne orthoflavivirus that causes severe encephalitis, long-term neurologic sequelae, and death, yet no approved antiviral therapies exist. Here, we evaluated several previously characterized nucleoside analogs as candidate countermeasures for POWV encephalitis. Favipiravir, molnupiravir, 4'-fluorouridine (4'-FlU), and GS-441524 inhibited POWV replication…
A partnership between the Bauchi govt, UNICEF and the US govt has lifted over 40,000 children out of malnutrition through targeted nutrition interventions.
The Lagos State AIDS Control Agency has warned that stigma, discrimination, and gender-based violence could frustrate efforts to control HIV in the state.
'This is not on the radar of a lot of seniors,' said Larry Mathieson, president and CEO of Unison at Kerby Centre. 'They probably don't need an extra cost at this point'
The Kwadaso Municipal Assembly in the Ashanti Region has commissioned and handed over a fully furnished Community-based Health Planning and Services (CHPS) compound at Nyankyerenease to bring closer…
Congo is running short of health workers to staff treatment centers for history's fastest-growing Ebola outbreak, particularly in the eastern province of North Kivu where cases have surged 73% over…
