Symmetric Dimethylarginine Modification Drives Shared and Divergent Antigen Reactivity in Lupus

Systemic lupus erythematosus (SLE) features a broad array of autoantibodies against nuclear components, but the mechanisms driving this diversity are poorly understood. We investigated whether posttranslational arginine methylation creates common neo-epitopes that could unify this response. Using methylome-wide peptide arrays, we identified anti-symmetric dimethylarginine (SDMA) autoantibodies in…

biorxiv.org ·16h ago

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