Structural Adaptability in HIV-2 Vif Drives Broad Antagonism of APOBEC3G
APOBEC3G (A3G), a restriction factor, is a barrier for zoonosis and targeted for degradation by the lentiviral protein Vif. Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 arose from transmissions of lentiviruses from Old World monkeys to hominid primates. While HIV-1 Vif needed to adapt to specific residues in the arms race interface with A3G, HIV-2 Vif has greater tolerance for diversity…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
