PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery
Massive library-based platforms enable rapid early hit discovery, yet subsequent hit resynthesis and validation remain major bottlenecks in drug discovery. This delay is amplified when optimizing hits, or elaborating structures towards more advanced modalities, such as chemical inducers of proximity (CIPs). Here, we report PROXINAUT, an end-to-end workflow integrating self-encoded library-based…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
