Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring
Accurate chromosome segregation relies on kinetochores maintaining load-bearing attachments to dynamic microtubule ends, a coupling in which the Dam1 complex ring is central. How the microtubule-end structure and ring-microtubule interactions collectively determine attachment stability and drive force transduction remains unresolved. Here, we use multiscale modeling to show that the ring forms a…
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