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Review of Prepregnancy Care and Counseling

To the Editor I appreciate the expanded women’s health learning opportunities provided by the JAMA Network journals under the editorial leadership of Linda Brubaker, MD, MS. The comprehensive Review of prepregnancy care and counseling by Dr Cooper and colleagues will be a valuable resource for clinicians caring for women of reproductive age. I am curious whether the authors recommend…

The article by Dr. Cooper and colleagues on prenatal care and counseling omitted the vital topic of iron deficiency screening. Iron deficiency, the most widespread micronutrient deficiency, plagues a significant portion of young women, with studies indicating a prevalence of around 38% when using a ferritin threshold of 30 μg/L. Despite this, discussions surrounding the most common cause, heavy menstrual bleeding, are often absent, leading to symptoms being overlooked and normalized.

Iron deficiency's prevalence varies during pregnancy, with studies showing a range from 21% to 84% at different gestational stages, with the strongest predictor of severe deficiency in the third trimester being a ferritin level of less than 60 μg/L at 15 weeks. Research also suggests a link between maternal iron deficiency and adverse outcomes in offspring, such as language and motor skill impairments at 2 years of age.

The consequences of iron deficiency, whether anemic or not, extend to symptoms like fatigue, restless legs syndrome, pica, and cognitive fog. Economic analyses suggest that screening for iron deficiency and treating it when detected are cost-effective in reproductive-aged women. Consequently, several professional organizations, including the International Federation of Gynecology and Obstetrics, the European Hematology Association, and others, now endorse screening for iron deficiency before pregnancy, as it's highly prevalent and can have significant health implications for both mothers and their future children.

Therefore, the article aligns with the growing trend of recommending iron deficiency screening for all reproductive-aged and pregnant women, regardless of anemia.

Written by urgent.news from JAMA's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.

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