Thirty years of fluconazole therapy selects an azole-resistant Candida albicans isolate with a pre-adapted physiological, metabolic and structural state
Azole resistance in Candida albicans is traditionally attributed to alterations in drug targets and efflux mechanisms; however, how long-term antifungal exposure reshapes fungal physiology remains incompletely understood. Here, we characterize a fluconazole-resistant C. albicans clinical isolate (PUJ256) recovered from a patient with chronic mucocutaneous candidiasis after more than 30 years of…
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