The impact of alpha synuclein overexpression on nigrostriatal transmission

Accumulation of wild type synuclein in dopamine neurons of the Substantia Nigra pars compacta is a pathological hallmark of Parkinson's disease (PD), which commonly precedes neurodegeneration. Yet how synuclein accumulation affects nigrostriatal neurotransmission early in the progression of PD remains poorly understood. In addition to axonal dopamine release, SNc neurons also co-release GABA and…

biorxiv.org ·1d ago

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

Read the original at biorxiv.org →

More in Science

Effect of high-intensity interval or continuous moderate exercise on cognition in a mouse model of mild cognitive impairment

Scientific Reports, Published online: 21 September 2026; doi:10.1038/s41598-026-69108-y Effect of high-intensity interval or continuous moderate exercise on cognition in a mouse model of mild…

1d ago ·nature.com

Evaluation of the accuracy of SWOT satellite observations for monitoring lake water levels in the Yangtze River Basin

Scientific Reports, Published online: 21 September 2026; doi:10.1038/s41598-026-72374-5 Evaluation of the accuracy of SWOT satellite observations for monitoring lake water levels in the Yangtze River…

1d ago ·nature.com

'Rusty Treasure' in Austria Revealed as Europe's Largest Cache of Iron Age Iron Bars

500 swords' worth. Don't miss a story, subscribe here.

1d ago ·sciencealert.com

Does a low resting heart rate actually cause antisocial behavior?

Using genetic data from thousands of twins, researchers have challenged a long-held psychological theory. They found little evidence that resting heart rate causes antisocial behavior, pointing instead to sensation seeking as a key target for behavioral therapies.

1d ago ·psypost.org

Why does your brain mix up memories? New study examines how memories are misplaced in your brain's filing cabinets

Old age and forgetfulness seem to go hand in hand. But my colleagues and I found that memories actually become less precise, not entirely forgotten. Our study, published in the journal Cerebral Cortex, shows how the brain blends related experiences as you age rather than replaying the exact one you need.

1d ago ·medicalxpress.com

British food was complex, multicultural and flavorful in the 18th century—despite what you might think

The stereotype of bland British food is notorious, and people mock the horrors of jellied eels and overcooked vegetables. Even roast beef and pudding are seen as uninspired compared with the cuisines of other nations. But British food is and has historically been complex, multicultural and flavorful.

1d ago ·phys.org