stEDGE enables edge-guided multiscale reconstruction of hierarchical spatial domains and transition interfaces in spatial transcriptomics
Spatial transcriptomic technologies enable high-resolution mapping of tissue architecture, yet most computational methods still represent tissues as flat spatial partitions, limiting their ability to resolve spatial domain boundaries, gradual transition regions and nested hierarchies. Here we present stEDGE, an edge-guided and interpretable framework for multiscale reconstruction of spatial…
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