Identification of co-expressed gene sets for major molecular initiating events in rodent liver carcinogenesis using wild type and knock out rats
Liver tumors are the most common carcinogenic outcome observed in two-year bioassays used for regulatory risk assessment of chemicals and pharmaceuticals. Because these traditional long-term studies are resource-intensive and not feasible for most chemicals, there is a critical need to develop alternative approaches that can identify potential rodent liver carcinogens in short-term studies (e.g.,…
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