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Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis

Current human mycobiome profiling relies largely on marker-based methods with limited sensitivity, whereas genome-based approaches require computationally intensive alignment against broad fungal references. Here, we present MycobiomeDB, a unified fungal genome catalog, and derive body-site-specific catalogs for the gut, oral cavity, skin, and vagina through metagenome-guided stratification.…

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