Emergent catch bonds from slip-like contacts: cooperative force-driven proofreading at receptor--ligand interfaces
Mechanical forces modulate receptor-ligand kinetics, sometimes producing the so-called catch bond: a tensile force strengthens the bond, whereas in most cases engagement time is reduced (a slip bond). Multiple phenomenological models reproduce catch-slip behavior between receptors and ligands, primarily by positing how the reaction's free-energy landscape changes under applied forces. In this…
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