SMORE: joint dimension reduction and cell population discovery on single-cell methylome data
Single-cell DNA methylation profiling technology captures novel epigenetic data modality but are challenging to analyze because of their heterogeneity, high dimensionality, and ultra-sparsity. Here we present SMORE (Single-cell MethylOme Reduction and Embedding), a computational method for joint dimensionality reduction and cell population discovery dedicated to single-cell DNA methylation data.…
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