CUBE: Multimodal Representation Learning Reveals Biological Structure Across Histomorphology, Spatial Protein Phenotypes, and Transcriptome-Associated Signals
Integrating histological, spatial protein, and transcriptomic information into a biologically grounded representation remains challenging because these modalities are rarely available as fully paired measurements, while existing computational approaches are commonly developed around individual modality pairs. To address this, we present CUBE (Colorectal Universal Representation & Bridge Encoder),…
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