Model-Free, Pure Component Analysis Could Help Biopharma Cut Costs
Spectroscopic analysis techniques rely on empirical models that are time consuming and expensive to make. Biopharma companies could speed development and reduce costs using a model-free measuring approach called pure-component analysis, says Nirrin Technologies. The post Model-Free, Pure Component Analysis Could Help Biopharma Cut Costs appeared first on GEN - Genetic Engineering and…
Spectroscopy aids in real-time analysis of proteins and analytes in process streams. However, many techniques like NIR and Raman depend on models to separate signals from noise. These models are costly and time-consuming to develop, requiring custom experiments and rework when conditions change. Nirrin Technologies, led by Bryan Hassell, proposes an alternative called "pure-component analysis."
This model-free approach directly resolves measured spectra into component concentrations, without the need for empirical models or design of experiments (DOE) campaigns. Nirrin's new tunable laser near-infrared (TL-NIR) platform, showcased at BPI East, exemplifies this. With a tunable laser delivering higher optical power to individual wavelengths, TL-NIR offers a significantly higher signal-to-noise ratio than conventional NIR.
The TL-NIR platform also provides direct concentrations instead of requiring spectral interpretation, enabling engineers to make decisions based on real-time data. Additionally, TL-NIR proves faster, requiring no sample preparation, dilution, or pathlength adjustments. For protein analysis, TL-NIR is five times faster than variable-pathlength UV and can replace costly HPLC measurements sent to external labs.
Currently, five to ten biopharma firms use TL-NIR in development, with plans to raise awareness for commercial production. The technology is already proven in development, with manufacturers gradually adopting it for production.
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