Regeneration-associated utrophin expression in skeletal muscle: implications for utrophin-targeted therapies
Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused by loss of dystrophin. Utrophin, a structural and functional paralogue of dystrophin, can compensate for dystrophin deficiency and represents a therapeutic target applicable to patients irrespective of their DMD mutation. However, utrophin is also naturally upregulated at the sarcolemma of regenerating…
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