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Microprotein Atlas Links Brain Immune Cell Dysfunction to Alzheimer’s

Built from transcriptomic and mass spectrometry data, the atlas uncovered more than 1,000 previously uncharacterized microproteins and pointed to a potential connection between one microprotein and…

  • Scientists at Salk Institute unveil first comprehensive microprotein atlas in human frontal cortex.
  • Microproteins, tiny proteins from small ORFs, found to be linked to Alzheimer's disease.
  • MKKS locus microprotein downregulated in Alzheimer's, linked to microglial bioenergetics.

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