A frozen human wound-repair reference reveals heterogeneous tumor niches and conditional immunotherapy associations
Purpose Tumors are often framed as unresolved wounds, but the extent to which independently defined physiological repair programs are recontextualized across cancers remains uncertain. Methods We derived five lineage-associated modules and a composite score from 58,823 cells in a longitudinal human skin-wound cohort before examining tumors. Frozen modules were evaluated in paired hepatocellular…
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