Transdermal diagnosis and therapy using an integrated acoustofluidic patch
Transdermal biosensing and drug delivery provide convenient, pain-free, and user-friendly solutions for personalized therapy. However, challenges remain in detecting and treating acute diseases, primarily due to current limitations in effective detection of transdermal biomarkers and administration of therapeutics to an individual within a short time window in a real-world environment. Here, we…
A new transdermal patch has been developed that combines transdermal biosensing and drug delivery into one compact device. This patch offers a pain-free and user-friendly way to detect and treat acute diseases. The challenge with current methods is the limited ability to effectively detect transdermal biomarkers and administer therapeutics quickly in real-world situations.
The patch features an acoustofluidic system that utilizes acoustic streaming and 3D-printed microfluidics. These elements work together to penetrate the skin's stratum corneum, sample interstitial fluids, and deliver therapeutics in a controlled manner. An electrochemical sensing module is included to detect transdermal biomarkers rapidly and deliver therapeutics through a closed-loop system.
To demonstrate the patch's capabilities, researchers used it to detect and treat anaphylaxis in a mouse model. The patch successfully sampled and measured transdermal histamine, then automatically delivered epinephrine to reverse the life-threatening reaction. This proof-of-concept suggests that the acoustofluidic patch could lead to a new class of transdermal devices for personalized therapy of various acute diseases.
Written by urgent.news from bioRxiv's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
