Exosomal miR-23a release coincides with astrocytic calcineurin activation, protects neurons from apoptosis by regulating NOXA in Parkinson's disease models and is enriched in the plasma of patients with Parkinson's disease
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and degeneration of their projections in the striatum (STR) of the brain. Astrocytes are recognized as active contributors to PD pathogenesis, yet the role of calcineurin (CN), a Ca/calmodulin-dependent phosphatase which is well characterized in neurons, remains…
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