Maintaining transcriptome solubility constrains mRNA sequence composition

Proceedings of the National Academy of Sciences, Volume 123, Issue 38, September 2026. SignificanceRNA base-pairing enables folding and regulation, but it also creates pervasive opportunities for unintended RNA–RNA interactions in the crowded intracellular environment. We identify this as a transcriptome-scale physical problem. Simulations ...

pnas.org ·8d ago

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