De novo mutations bridge parental reproductive factors and offspring health
Nature Medicine, Published online: 14 September 2026; doi:10.1038/s41591-026-04676-0 Whole-genome sequencing of 7,851 parent–offspring families enabled the identification of parent-of-origin and post-zygotic de novo mutations that were associated with distinct procedures of assisted reproductive technology (ART), independently of parental age at conception. Increased paternal mutational burden…
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