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The Iowa vs. Iowa State rivalry game, the 73rd Cy-Hawk Trophy matchup, is set to take place. Iowa State has won the last two meetings between the two teams, and it's time to provide a prediction and pick for the upcoming game. Iowa enters the game with a perfect 1-0 record and currently ranks in the Top 25. Their offense was dominant in their first game, with 26 first downs and 507 yards of offense.

Key contributors included Kamari Moulton, who ran for 183 yards and two touchdowns on just 11 carries. Iowa State enters with a 1-0 record as well, after a win over Southeast Missouri State. Their offense had 303 yards and four first downs, while the defense held Southeast Missouri State to 209 yards and forced three turnovers. The all-time series is 46-25 in favor of Iowa State, with Iowa State winning three of the last four.

DraftKings odds have Iowa State at +14 (-112) and Iowa at -14 (-108). The under has been dominant in the past, hitting in six of the last seven games and eight of the last ten. Historically, the underdog has covered the spread six times in the last eight games, and the road team has lost just four times since 2010. For Iowa State, managing mistakes will be crucial.

Quarterback Jaylen Raynor threw 52 touchdowns to 29 interceptions in his previous three seasons at Arkansas State, but threw for just 184 yards and multiple interception opportunities against Northern Illinois last week. On defense, Iowa State should stack the box to counter Iowa's running game, led by Kamari Moulton, who averages over 5.5 yards per carry.

For Iowa, dealing with their quarterback situation will be key. Both Hank Brown and Jeremy Hecklinski are expected to play and split reps. With Iowa's run-heavy offense, the quarterback will need to be a game manager. Defensively, Iowa needs to pressure Iowa State's quarterback and force mistakes through turnovers. Considering home field advantage has been minimal in this series, the prediction is Iowa -14 (-108) and the under at 40.5 (-108).