Loss of function of LprG-Rv1410c and MmpL11 homologues in Mycobacterium smegmatis leads to altered glycopeptidolipid profile and decreased cellular c-di-GMP levels during biofilm formation
The cell envelope of many bacteria possesses components that play central roles in bacterial pathogenesis. Unique to mycobacteria is the presence of a lipid-rich cell wall which is critical for the virulence of pathogenic mycobacteria such as Mycobacterium tuberculosis (Mtb). The biosynthesis of mycobacterial cell wall lipids has been well characterized, but the mechanisms of lipid transport…
The loss of function in LprG-Rv1410c and MmpL11 homologues in Mycobacterium smegmatis results in alterations to the glycopeptidolipid profile and reduced levels of cellular c-di-GMP during biofilm formation. Both pathways are involved in modulating c-di-GMP levels, but LprG-Rv1410c is crucial for regulating glycopeptidolipid (GPL) synthesis and surface localization, while MmpL11 may fine-tune GPL levels more generally.
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