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Genome mining of coastal cenote sediment-associated Streptomyces sp. NCA360 strain uncovers novel biosynthetic gene clusters and their regulatory architecture

The rise of antibiotic resistance has intensified the search for novel antimicrobial compounds, and bioprospecting of natural products from underexplored environments remains an effective strategy. The genus Streptomyces is one of the most prolific sources of pharmacologically active secondary metabolites, whose biosynthetic information is encoded in biosynthetic gene clusters (BGCs). However,…

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