De novo design of allosterically controlled enzymes
The ability of enzymes to sense signals and respond by changing their structure and activity underlies cellular processes from signaling to metabolic control. While there have been recent advances in the de novo design of enzymes and conformationally switching proteins, combining these to achieve allosteric regulation of enzymatic activity in a fully designed system remains an outstanding…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
