A single-nucleus and spatial transcriptomic atlas of the Syrian hamster preoptic area across hibernation states
Hibernation is an extreme physiological state in certain mammals that is characterized by a reversible reduction in metabolic and thermogenic demands. Although the preoptic area has been implicated in the regulation of hibernation, comprehensive molecular and spatial resources for this brain region in hibernating mammals remain limited. Here, we present an integrated transcriptomic resource of…
Hibernation, a reversible reduction in metabolic and thermogenic demands, is observed in certain mammals. Despite its known role in regulating hibernation, limited molecular and spatial resources exist for the preoptic area in hibernating mammals. A team has now developed a comprehensive transcriptomic resource for this brain region using single-nucleus RNA sequencing (snRNA-seq) and Xenium-based spatial transcriptomics in Syrian hamsters.
This resource encompasses cross-species transcriptomic annotations compared to mouse preoptic area datasets, seasonal snRNA-seq datasets under non-hibernating and hibernating conditions, and spatially resolved cell-type annotations derived from Xenium profiling. The collective data establishes a framework for identifying neuronal populations, assessing molecular conservation across species and conditions, and linking transcriptomic identity with spatial organization.
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