Positive data revealed for patients with a heart attack and multivessel disease
Functional coronary angiography significantly reduced cardiovascular events and improved safety compared with conventional angiography in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease. This was the main conclusion of the AIR-STEMI trial presented in a Hot Line session at ESC Congress 2026 and published simultaneously in the New England Journal of…
A recent trial presented at the ESC Congress 2026, titled AIR-STEMI, has revealed positive data for patients with a heart attack and multivessel disease. The study found that functional coronary angiography significantly reduced cardiovascular events and improved safety compared to conventional angiography. Multivessel coronary artery disease, where at least two coronary arteries are blocked, affects almost half of patients who have STEMI, a common type of heart attack.
The trial, conducted in 21 centers across Italy and Pakistan, compared functional coronary angiography with conventional angiography in patients with STEMI and multivessel disease who had undergone successful PCI for the culprit lesion. The functional approach used angiography-derived fractional flow reserve (FFR) to assess non-culprit lesions, identifying those that required treatment.
In the functional coronary angiography group, 51.9% of non-culprit vessels underwent PCI, compared to 94.9% in the angiography-guided group.
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