Estimated glucose disposal rate inversely linked to benign prostatic hyperplasia
There is a negative link between estimated glucose disposal rate (eGDR) and benign prostatic hyperplasia (BPH) in men, according to a study published online Aug. 25 in The Aging Male.
A recent study published in The Aging Male has found a negative link between estimated glucose disposal rate (eGDR) and benign prostatic hyperplasia (BPH) in both American and Chinese populations. The research, conducted by Haowen Liang and colleagues from Liuzhou Traditional Chinese Medical Hospital, analyzed data from the China Health and Retirement Longitudinal Study and the National Health and Nutrition Examination Survey, involving a total of 7,845 participants.
The study revealed a significant inverse relationship between eGDR and BPH risk, confirmed by a linear relationship observed in a restricted cubic spline analysis of both datasets. This association remained consistent across various subgroups within the study populations. Notably, the effect of eGDR on BPH risk was found to be mediated by monocytes at a rate of 15.14% in the U.S. cohort.
The findings suggest that eGDR may serve as a valuable indicator of insulin resistance, which could aid in the risk stratification of BPH. This adds to the growing body of knowledge on the relationship between insulin resistance and BPH development. The authors propose that managing central obesity and reducing chronic inflammation linked to insulin resistance may help lower the incidence of BPH. Furthermore, they highlight the monocyte inflammatory pathway as a potential therapeutic target for addressing BPH.
Written by urgent.news from Medical Xpress's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
