2011 to 2021 saw heart failure-related hospitalization rise in CKD
For patients with advanced chronic kidney disease (CKD), rates of heart failure-related hospitalization increased from 2011 to 2021, according to a study published in the September issue of Kidney International Reports.
Between 2011 and 2021, rates of heart failure-related hospitalization climbed significantly among patients with advanced chronic kidney disease (CKD), according to a study published in the September issue of Kidney International Reports. Researchers from Karolinska Institutet in Stockholm analyzed data from 25,591 and 13,968 patients with stages G4 and G5 CKD, respectively, as well as 10,635 patients on hemodialysis and 4,511 on peritoneal dialysis.
Compared to the general population, these advanced CKD stages exhibited heart failure-related hospitalization rates that were 3.7 to 6.8 times higher. Despite stable use of renin-angiotensin system inhibitors (RASi) and beta-blockers, diuretic prescriptions decreased in non-dialysis CKD. This aligns with larger increases in heart failure-related hospitalization for G4, G5 non-dialysis CKD, and hemodialysis patients (+51%, +36%, and +30%, respectively) compared to the general population.
However, heart failure-related mortality in both non-dialysis and dialysis-dependent CKD declined, albeit more slowly than in the general population. The study highlights the growing cardiovascular burden in patients with advanced CKD and calls for optimized evidence-based treatment strategies tailored to this high-risk population.
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