Peroxisome structure can help protect insulin and maintain beta cell health
Researchers at LSU's Pennington Biomedical Research Center have identified a previously underappreciated role for tiny structures inside cells called peroxisomes in protecting insulin and maintaining the health and maturity of insulin-producing pancreatic beta cells.
Researchers at LSU's Pennington Biomedical Research Center have discovered that tiny cell structures called peroxisomes play a crucial role in protecting insulin and maintaining the health of insulin-producing beta cells in the pancreas. Located within cells, peroxisomes help remove harmful substances and break down fats. In experiments on animals, researchers found that disrupting peroxisomes damaged beta cells in three ways: promoting oxidative stress, altering insulin's chemical structure, and reducing signs of full maturity and normal functioning.
Despite releasing more insulin in response to sugar, these animals were less able to control blood sugar levels. The study, published in JCI Insight, reveals how cellular issues may contribute to the decline in healthy insulin production observed in diabetes.
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