MRI may help predict progression in early-onset Alzheimer's disease

A study by researchers at Mass General Brigham Neuroscience Institute reveals that measuring brain atrophy through MRI scans could help predict how quickly early-onset Alzheimer's disease progresses. Early-onset Alzheimer's, which manifests before the age of 65, progresses faster than the more common later-onset form but the rate of progression varies widely among individuals, making it difficult to predict.

In a study involving 130 participants aged 40-64 with early-onset Alzheimer's-related mild cognitive impairment, greater shrinkage in memory and cognitive regions on MRI scans was associated with a higher likelihood of developing dementia within two years. The research, published in Neurology, suggests that incorporating MRI measures into clinical practice could aid in planning future care and support for patients and their families.

However, further studies are needed to validate the MRI measure across diverse populations and to determine its usefulness in predicting important outcomes such as institutionalization or mortality.