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Neural Mechanism Identified That Drives Increased Alcohol Use in Isolated Male Mice

A study in mice has found that loneliness can reprogram the brain in ways that promote alcohol consumption, and identified a neural mechanism through which isolation escalates alcohol use in male…

  • Basolateral amygdala and medial prefrontal cortex drive increased alcohol use in isolated male mice.
  • Social isolation heightened excitability in BLA-mPFC pathway in males, decreased it in females.

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