Structural basis of GSDME pore formation and its regulation by S-palmitoylation
Proceedings of the National Academy of Sciences, Volume 123, Issue 35, September 2026. SignificanceGasdermin E (GSDME) links apoptosis to pyroptosis, but the structural mechanism of its pore formation remains unknown. Our cryo-electron microscopy structure of the GSDME pore establishes a general framework for gasdermin-mediated membrane ...
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