Epithelial and γδ T cell CD47 have complementary yet distinct roles in regulating γδ intraepithelial lymphocyte migration
Intraepithelial lymphocytes expressing the {gamma}{delta} T cell receptor ({gamma}{delta} IEL) continuously survey the intestinal epithelium to promote mucosal host defense. Although {gamma}{delta} IELs migrate in and out of the lateral intercellular space (LIS) between adjacent enterocytes, the molecular mechanisms governing their migratory behavior are incompletely understood. Based on the…
Intraepithelial lymphocytes, known as {gamma}{delta} IELs, actively patrol the intestinal epithelium to defend against pathogens. While the mechanisms behind their migration between enterocytes are not fully understood, researchers have discovered that CD47 plays a crucial role in this process. In a study examining the impact of CD47 deletion on {gamma}{delta} IELs, they found that its expression does not affect the composition of these cells.
Intravital imaging revealed a dual role for CD47, with epithelial cells restricting {gamma}{delta} IEL motility and {gamma}{delta} T-cells promoting their migration. Further analysis showed that both CD47 and CD18 contribute to {gamma}{delta} IEL surveillance, with CD47 exerting its influence independently of CD18.
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