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The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

Circulating tumor cells (CTCs) encounter multiple challenges within the blood microenvironment, including oxidative stress, flow shear forces, and immune surveillance, often leading to anoikis. Recently, a transitional state of CTC senescence has been identified, contributing to metastatic inefficiency. However, the molecular mechanisms linking senescent CTCs to disease relapse remain to be…

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

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Building-level wastewater surveillance of antimicrobial resistance in the general, student and hospital-associated populations

Scientific Reports, Published online: 20 August 2026; doi:10.1038/s41598-026-67590-y Building-level wastewater surveillance of antimicrobial resistance in the general, student and hospital-associated…

  • Wastewater surveillance tracks AMR in Perugia's general, student, and hospital populations
  • Third-generation cephalosporin resistant E. coli prevalence consistent across populations
  • Vancomycin-resistant enterococci levels highest in hospital wastewater

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