Andrea Maier Wants to Solve Longevity's Evidence Problem

Dr. Andrea Maier's passion for studying aging began during her medical school years, inspired by great-grandmothers who embodied wisdom and vitality. She now leads the Academy for Healthy Longevity at the National University of Singapore, opening a new clinical trial center in 2025 to run multiple long-term trials of supplements, exercise routines, and lifestyle interventions aimed at improving health span.

Her research on drugs and interventions that prolong the lives of mice, including NMN and AKG, has earned her a leading role in longevity medicine globally. The new center aims to generate evidence to solidify longevity medicine's scientific foundation and train future doctors in longevity science. Unlike most studies, Maier's trials focus on individuals with a biological age older than their chronological age, increasing the likelihood of detecting beneficial effects of interventions.

This approach also aligns with her vision of personalized medicine, where plans are tailored to each patient's unique biology. Her PROMETHEUS trial, which tested personalized dietary, exercise, supplement, and cognitive behavioral therapy interventions, yielded promising results in a pilot with 20 participants. The team is currently planning a randomized controlled trial to assess the long-term health effects of these interventions over a year.