Mouse study reveals candidate proteins for liver disease diagnosis and treatment monitoring
Researchers from Skoltech and their colleagues from the N.N. Petrov National Medical Research Center of Oncology have identified proteomic markers for monitoring liver injury and confirmed the hepatoprotective effects of plant polyphenols.
Researchers from Skoltech and the N.N. Petrov National Medical Research Center of Oncology have identified potential protein markers that could be used to monitor liver injury and evaluate the effectiveness of liver-protective treatments. These markers, discovered through a multi-omics approach using mass spectrometry, have the potential to enable minimally invasive blood and plasma tests for early liver injury diagnosis and treatment monitoring.
The findings, published in the International Journal of Molecular Sciences, suggest that plant polyphenol-based drugs may also offer hepatoprotective benefits, as demonstrated in mouse models. The drugs showed improved survival rates and positive histological outcomes without exhibiting toxicity or mutagenic properties. This research, led by a team from Skoltech's Laboratory of Omics Technologies and Big Data for Personalized Medicine and Health, could pave the way for future personalized medicine applications and clinical trials of new hepatoprotective drugs.
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