Phosphorylation alters the bulk chemical properties of Orc1 to tune DNA binding, phase separation, and heterochromatin partitioning.
The first step in initiating DNA replication is binding of the origin recognition complex (ORC) to chromosomes. Metazoan ORC is recruited to chromatin via the Orc1 intrinsically disordered region (IDR) whose DNA and chromatin binding activity are regulated by Cyclin Dependent Kinase (CDK) phosphorylation. ORC is also enriched in heterochromatin where it is required for the formation and…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
